Cefazolin for injection and other antibacterial drugs, Cefazolin for injection should be A Pharmacy Bulk Package is sterile dosage form for parenteral use that. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefazolin for Cefazolin for Injection, USP is a semi-synthetic cephalosporin for parenteral administration. .. For IV Administration: See package insert. Page 2 of PRODUCT MONOGRAPH. Pr. Cefazolin for Injection USP. THERAPEUTIC CLASSIFICATION. Antibiotic. ACTION AND CLINICAL.

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If particulate matter is evident in reconstituted fluids, the drug solutions should be discarded. Reconstituted solutions may range in color from pale yellow to yellow without a change in potency.

Prior to administration parenteral drug products should be inspected visually for particulate matter and discoloration whenever solution and container permit. As with other cephalosporins, reconstituted Cefazolin for Injection, USP tends to darken depending on storage conditions, within the stated recommendations.

However, product potency is not adversely affected. Check for minute leaks by squeezing container firmly. If leaks are detected, discard solution as sterility may be impaired. As with other cephalosporins, cefazolin tends to darken depending on storage conditions; within the stated recommendations, however, product potency is not adversely affected.

Handle frozen product containers with care. Product containers may be fragile in the frozen state. Most strains of indole positive Proteus Proteus vulgarisEnterobacter spp.

Respiratory Tract Infections Due to S. Injectable benzathine penicillin is considered to be the drug of choice in treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever.

ANCEF is effective in the eradication of streptococci from the nasopharynx; however, data establishing the efficacy of ANCEF in the subsequent prevention of rheumatic fever are not available. Biliary Tract Infections Due to E. Septicemia Due to S. Endocarditis Due to S.

Appropriate culture and susceptibility studies should be performed to determine susceptibility of the causative organism to ANCEF.


Perioperative Prophylaxis The prophylactic administration of ANCEF preoperatively, intraoperatively, and postoperatively may reduce the incidence of certain postoperative infections in patients undergoing surgical procedures pacjage are classified as contaminated or potentially contaminated e.

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The perioperative use of ANCEF may also be effective in surgical patients in whom infection at the operative site would present a serious risk e. The prophylactic administration of ANCEF should usually be discontinued within a hour period after the surgical procedure. In surgery where the occurrence of infection may be particularly devastating e.

If there are signs of infection, specimens for cultures should be obtained for the pac,age of the causative organism so that appropriate therapy may be instituted. To reduce the development of drug-resistant bacteria and maintain the effectiveness amcef ANCEF and other antibacterial drugs, ANCEF should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

Cefazolin for Injection, USP – WG Critical Care

When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Pseudomembranous colitis has been inert with nearly all antibacterial agents, including cefazolin, and may range in severity from mild to life-threatening.

Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent inser the administration of antibacterial agents. Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia.

After the diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, packag should be given to management with fluids and electrolytes, protein supplementation, and treatment with an oral antibacterial drug clinically effective against C.

All reduced dosage recommendations apply after an initial loading dose appropriate to the severity of the infection. Perioperative Prophylactic Use To prevent postoperative infection in contaminated or potentially contaminated surgery, recommended doses are:. For lengthy operative procedures e. Pediatric Dosage In pediatric patients, a total daily dosage of 25 to 50 mg per kg approximately 10 to 20 mg per pound of body weight, divided into 3 or 4 equal doses, is effective for most mild to moderately severe infections.


Total daily dosage may be increased to mg per kg 45 mg per pound of body weight for severe infections. Since safety for use in premature infants and in neonates has not been established, the use of ANCEF in these patients is not recommended. All dosage recommendations apply after an initial loading dose.

Discard vial within 4 hours after initial entry. When adding diluent to vial, allow air to escape by using a small vent needle or by pumping the syringe. Administer with primary IV fluids, as a single dose. Shake well until dissolved. ANCEF should be injected into a large muscle mass. Intravenous Administration Direct bolus injection: Following reconstitution according to the above table, further dilute vials with approximately 5 mL Sterile Water for Injection.

Inject the solution slowly over 3 to 5 minutes, directly or through tubing for patients receiving parenteral fluids see list below. Intermittent or continuous infusion: L60 Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Urinary Tract Infections Due to E. Bone and Joint Infections Due to S. Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment.

Severe, life-threatening infections e.