, Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B Hille. The Journal of general physiology 69 (4), Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na + and K + channels of axons. Ionic Channels of Excitable Membranes by Bertil Hille (). $ Hardcover. Books by Bertil Hille. Showing 3 Results Books: Advanced Search.

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So there are many people who came through the house and were excellent scientists; the idea of science was just a given. And that was quite a fascinating learning experience. Hydrophilic and hydrophobic pathways for the drug-receptor reaction. Let’s hillle if you had seven charges in a row, each of them could move a seventh of the way through the field for an equivalent electrical charge movement of one electronic charge.

Also we were able to identify charge that, at least in theory, would make the channel nonconductive betil that it did not reflux through the open state during recovery from inactivation. Well, so we sort of skipped over what we knew at the time. Characteristic, I might say, of the general type of person who has always worked in the field.

And then the future. And then there’s, of course, his great book, which is extremely influential. Bertil Hille pioneered the concept of ion channels as membrane proteins forming gated aqueous pores with Clay Armstrong.

Bertil Hille

If I remember correctly the Meves-Chandler paper did not use organics. Potassium channels as multi-ion single-file pores. As a graduate student perhaps the best paper that came out when I started was the paper by Chandler and Meves, where they had done this berfil that Hodgkin said was going on in Plymouth—perfusion—and they showed that the sodium channel of the squid axon can accept lithium, sodium, potassium, rubidium and cesium and gave permeabilities for each of those.


And I gradually began to feel that if you were interested in electronics and you had to use it, you didn’t have to be some electrical engineer to fix it because here was Fred Dodge, who had just come from New Hampshire and wasn’t an engineer, and he was enjoying it, and it was very rational. Actually when I finished at Plymouth, Alan Betil told me that there was no place for me to work in Cambridge, so I would have to do a theoretical problem.

So it all fitted with the idea that this one family of axons had two connections. No cell could exist without bertio channels. Adams University of Wollongong, Australia. Now in the literature there had already been papers by Koketsu and Bertill.

Bertil Hille – Google Scholar Citations

I think it is now clearly recognized by everyone that, in fact, there are direct projections from the lateral geniculate to some of the higher numbered areas. Handbook of Ion Channels. And Eduardo Rojas was in England at the time, and so he communicated some of this fervor to Pancho and to me.

But all those people were there still, and I knew them quite well and interacted with them.

Function and structure of ion channels

And so finally I had what I felt was the comprehensive list, and then I had to explain, what does it mean? Possibly linear, possibly helical. The system can’t perform the operation now. And he said, it has to be proteins! Well, epilepsy, for example, is one clear case. A very, very bertli and trying trip.

And I failed utterly to be able to do this. We didn’t have very rigorous training. Most impressive was the stunning visualization of three ions within the pore—two in the selectivity filter and one in a cavity near the membrane center.


He berttil certainly there. The patch clamp has allowed us to look at all cells.

Let’s say you had sodium ions on both sides, if you replace the sodium ions with a test ion, you now have to go to a different voltage to keep the net current from going outwards or inwards or it doesn’t stay the same. Richtmyer Cornell Physics Tree. The only reason that the medical student could possibly think that it is not important is that we don’t know enough yet.

So how was it that you went from the charge movement, the thing that you measure with electrical techniques and stuff, and then came up with the idea of the zipper scheme for what the charge movement was representing structurally?

Now this was the beginning of the graduate program at Rockefeller, if I remember correctly? In addition to identifying specific channels in cell membranes, Hille was fascinated to know how a molecular pore could recognize the difference between the tiny sodium and potassium ions.

Well, actually, one struggle that was going on at that time was people had, up until that time, wanted the hydrated ions to be what goes through the hole, and the hydrated ions were a big fuzzy ball surrounded by water.

So soon after that, I did the same hi,le, a little bit, myself at Rockefeller. Well, I was also surprised, I might say. And it was a wonderful department. Write a customer review.